Role of KRAS let-7 LCS6 SNP in metastatic colorectal cancer patients
نویسندگان
چکیده
منابع مشابه
Role of KRAS let-7 LCS6 SNP in metastatic colorectal cancer patients.
Role of KRAS let-7 LCS6 SNP in metastatic colorectal cancer patients We read with interest the study by Zhang et al. [1] on the association between the LCS6 T/G variant (rs61764370) and
متن کاملA let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer.
PURPOSE Colorectal cancer (CRC) is a common cause of death worldwide. Tumor-node-metastasis-system stage is currently used to guide therapy decisions but lacks precision. Prognostic biomarkers are needed to refine stratification of patients for chemotherapy but validated biomarkers are not yet available. Recently, a SNP in a lethal-7 (let-7) miRNA complementary site (LCS6) in the KRAS 3'untrans...
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Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Resul...
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There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region (UTR) of KRAS (KRAS-LCS6) for colorectal cancer outcome, although the results are conflicting. We performed a review and meta-analysis in an attempt to better clarify this relationship. A PubMed search was conducted to identify all studies ...
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Background: Mutations in the EGFR signaling pathway play an important role in the development of colorectal cancer (CRC). Mutations in these genes, like KRAS and BRAF, affect the treatment strategies and associated with poor prognosis and relative resistance to anti-EGFR therapies. Our aim was to conduct a systematic and meta-analysis on all studies that have been conducted on the prevalence of...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2011
ISSN: 0923-7534
DOI: 10.1093/annonc/mdq472